Sensation changes-Since nerves are damaged in GBS, your brain may receive abnormal sensory signals from the rest of your body. This results in unexplained, spontaneous sensations, called paresthesias, that you may feel as tingling, a sense of insects crawling under the skin (called formications), and pain. Most people reach the greatest stage of weakness within the first two weeks after symptoms appear by the third week 90 percent of affected individuals are at their weakest. Muscles controlling breathing can weaken to the point that you might need a machine to help you breathe.
Occasionally symptoms start in the upper body and move down to the legs and feet. Symptoms often affect the arms, breathing muscles, and even the face, reflecting more widespread nerve damage. You may first notice weakness as difficulty climbing stairs or with walking. Symptoms are usually equal on both sides of the body (called symmetric). Weakness-The weakness seen in GBS usually comes on quickly and worsens over hours or days. In these cases, the disorder is life-threatening-potentially interfering with breathing and, at times, with blood pressure or heart rate.
GBS can increase in intensity over a period of hours, days, or weeks until certain muscles cannot be used at all and, when severe, the person is almost totally paralyzed. After recovery, some people will continue to have some degree of weakness. Fortunately, most people eventually recover from even the most severe cases of GBS. GBS can range from a very mild case with brief weakness to nearly devastating paralysis, leaving you unable to breathe independently. Guillain-Barré syndrome (GBS) is a rare neurological disorder in which your immune system mistakenly attacks part of the peripheral nervous system-the network of nerves located outside of the brain and spinal cord.
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